Explain The Steps That Genetic Mutation Classifiers Use To Predict If This Mutat

Explain the steps that genetic mutation classifiers use to predict if this mutation is neutral or pathogenic. Example of mutation classifiers are PolyPhen-2, MutationTaster, Mutation Assessor, FATHMM, PANTHER, PhD-SNP, SNAP. They explain their way on their published paper but, I don’t understand it very well.